USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P02679 USC-OGP 2-DE database:  P02679 P02679 General information about the entry View entry in simple text format Entry name FIBG_HUMAN Primary accession number P02679 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Fibrinogen gamma chain; Flags: Precursor;. Gene name Name=FGG ORFNames=PRO2061 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0271: pI=5.36; Mw=135284 SPOT OGP-0272: pI=5.39; Mw=132990 SPOT OGP-0378: pI=5.24; Mw=48653 SPOT OGP-0380: pI=5.50; Mw=48298 SPOT OGP-0381: pI=5.62; Mw=48180 SPOT OGP-0382: pI=5.31; Mw=48062 SPOT OGP-0385: pI=5.41; Mw=47828 SPOT OGP-0388: pI=5.49; Mw=47595 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0612: pI=5.32; Mw=107319 SPOT OGP-0613: pI=5.25; Mw=106288 SPOT OGP-0614: pI=5.28; Mw=106288 SPOT OGP-0669: pI=5.53; Mw=51309 SPOT OGP-0672: pI=5.22; Mw=50928 SPOT OGP-0673: pI=5.28; Mw=50676 SPOT OGP-0674: pI=5.29; Mw=50676 SPOT OGP-0675: pI=5.41; Mw=50676 SPOT OGP-0680: pI=5.50; Mw=50050 SPOT OGP-0693: pI=5.56; Mw=44976 SPOT OGP-0698: pI=5.65; Mw=44642 Cross-references UniProtKB/Swiss-Prot P02679; FIBG_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name FIBG_HUMAN Primary accession number P02679 Secondary accession number(s) A8K057 P04469 P04470 Q53Y18 Q96A14 Q96KJ3 Q9UC62 Q9UC63 Q9UCF3 Sequence was last modified on  April 16, 2002 (version 3) Annotations were last modified on  March 15, 2017 (version 216) Name and origin of the protein Description RecName: Full=Fibrinogen gamma chain; Flags: Precursor; Gene name Name=FGG ORFNames=PRO2061 Encoded on Name=FGG; ORFNames=PRO2061 Keywords 3D-structure; Alternative splicing; Blood coagulation; Calcium; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemostasis; Isopeptide bond; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Sulfation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M10014; AAB59530.1; -; Genomic_DNA EMBL M10014; AAB59531.1; -; Genomic_DNA EMBL AF118092; AAF22036.1; -; mRNA EMBL AF350254; AAK19751.2; -; Genomic_DNA EMBL AF350254; AAK19752.2; -; Genomic_DNA EMBL AK289422; BAF82111.1; -; mRNA EMBL AK290824; BAF83513.1; -; mRNA EMBL BT007081; AAP35744.1; -; mRNA EMBL CH471056; EAX04917.1; -; Genomic_DNA EMBL CH471056; EAX04919.1; -; Genomic_DNA EMBL BC007044; AAH07044.1; -; mRNA EMBL BC021674; AAH21674.1; -; mRNA EMBL X51473; CAA35837.1; -; mRNA EMBL X00086; CAA24944.1; -; mRNA EMBL K02569; AAA52430.1; -; Genomic_DNA EMBL K02569; AAA52431.1; -; Genomic_DNA CCDS CCDS3788.1; -. [P02679-1]; . CCDS CCDS47153.1; -. [P02679-2]; . PIR A90470; FGHUG; . PIR A90494; FGHUGB; . RefSeq NP_000500.2; NM_000509.5. [P02679-2]; . RefSeq NP_068656.2; NM_021870.2. [P02679-1]; . UniGene Hs.727584; -; . PDB 1DUG; X-ray; 1.80 A; A/B=424-433 PDB 1FIB; X-ray; 2.10 A; A=169-433 PDB 1FIC; X-ray; 2.50 A; A/B=169-433 PDB 1FID; X-ray; 2.10 A; A=169-433 PDB 1FZA; X-ray; 2.90 A; C/F=114-432 PDB 1FZB; X-ray; 2.90 A; C/F=114-432 PDB 1FZC; X-ray; 2.30 A; C/F=114-432 PDB 1FZE; X-ray; 3.00 A; C/F=114-432 PDB 1FZF; X-ray; 2.70 A; C/F=114-432 PDB 1FZG; X-ray; 2.50 A; C/F=114-432 PDB 1LT9; X-ray; 2.80 A; C/F=122-432 PDB 1LTJ; X-ray; 2.80 A; C/F=122-432 PDB 1N86; X-ray; 3.20 A; C/F=114-433 PDB 1N8E; X-ray; 4.50 A; C/F=114-433 PDB 1RE3; X-ray; 2.45 A; C/F=122-432 PDB 1RE4; X-ray; 2.70 A; C/F=122-432 PDB 1RF0; X-ray; 2.81 A; C/F=122-432 PDB 1RF1; X-ray; 2.53 A; C/F=122-432 PDB 2A45; X-ray; 3.65 A; I/L=27-71 PDB 2FFD; X-ray; 2.89 A; C/F=122-432 PDB 2FIB; X-ray; 2.01 A; A=169-433 PDB 2H43; X-ray; 2.70 A; C/F=115-433 PDB 2HLO; X-ray; 2.60 A; C/F=114-433 PDB 2HOD; X-ray; 2.90 A; C/F/I/L=115-433 PDB 2HPC; X-ray; 2.90 A; C/F/I/L=115-433 PDB 2HWL; X-ray; 2.40 A; P=439-452 PDB 2OYH; X-ray; 2.40 A; C/F=122-432 PDB 2OYI; X-ray; 2.70 A; C/F=122-432 PDB 2Q9I; X-ray; 2.80 A; C/F=114-433 PDB 2VDO; X-ray; 2.51 A; C=426-433 PDB 2VDP; X-ray; 2.80 A; C=428-433 PDB 2VDQ; X-ray; 2.59 A; C=426-435 PDB 2VDR; X-ray; 2.40 A; C=428-452 PDB 2VR3; X-ray; 1.95 A; C/D=425-436 PDB 2XNX; X-ray; 3.30 A; C/F/I/L=114-432 PDB 2XNY; X-ray; 7.50 A; C/F=114-432 PDB 2Y7L; X-ray; 1.49 A; B=421-433 PDB 2Z4E; X-ray; 2.70 A; C/F=114-433 PDB 3BVH; X-ray; 2.60 A; C/F=128-420 PDB 3E1I; X-ray; 2.30 A; C/F=114-432 PDB 3FIB; X-ray; 2.10 A; A=170-418 PDB 3GHG; X-ray; 2.90 A; C/F/I/L=27-433 PDB 3H32; X-ray; 3.60 A; C/F=121-433 PDB 3HUS; X-ray; 3.04 A; C/F=122-432 PDB 4B60; X-ray; 1.83 A; C/D=421-433 PDBsum 1DUG; -; . PDBsum 1FIB; -; . PDBsum 1FIC; -; . PDBsum 1FID; -; . PDBsum 1FZA; -; . PDBsum 1FZB; -; . PDBsum 1FZC; -; . PDBsum 1FZE; -; . PDBsum 1FZF; -; . PDBsum 1FZG; -; . PDBsum 1LT9; -; . PDBsum 1LTJ; -; . PDBsum 1N86; -; . PDBsum 1N8E; -; . PDBsum 1RE3; -; . PDBsum 1RE4; -; . PDBsum 1RF0; -; . PDBsum 1RF1; -; . PDBsum 2A45; -; . PDBsum 2FFD; -; . PDBsum 2FIB; -; . PDBsum 2H43; -; . PDBsum 2HLO; -; . PDBsum 2HOD; -; . PDBsum 2HPC; -; . PDBsum 2HWL; -; . PDBsum 2OYH; -; . PDBsum 2OYI; -; . PDBsum 2Q9I; -; . PDBsum 2VDO; -; . PDBsum 2VDP; -; . PDBsum 2VDQ; -; . PDBsum 2VDR; -; . PDBsum 2VR3; -; . PDBsum 2XNX; -; . PDBsum 2XNY; -; . PDBsum 2Y7L; -; . PDBsum 2Z4E; -; . PDBsum 3BVH; -; . PDBsum 3E1I; -; . PDBsum 3FIB; -; . PDBsum 3GHG; -; . PDBsum 3H32; -; . PDBsum 3HUS; -; . PDBsum 4B60; -; . ProteinModelPortal P02679; -; . SMR P02679; -; . BioGrid 108557; 24; . DIP DIP-29644N; -; . IntAct P02679; 5; . MINT MINT-5004002; -; . STRING 9606.ENSP00000336829; -; . ChEMBL CHEMBL2364709; -; . DrugBank DB00364; Sucralfate; . iPTMnet P02679; -; . PhosphoSitePlus P02679; -; . UniCarbKB P02679; -; . BioMuta FGG; -; . DMDM 20178280; -; . DOSAC-COBS-2DPAGE P02679; -; . OGP P02679; -; . REPRODUCTION-2DPAGE IPI00219713; -; . REPRODUCTION-2DPAGE P02679; -; . SWISS-2DPAGE P02679; -; . MaxQB P02679; -; . PaxDb P02679; -; . PeptideAtlas P02679; -; . PRIDE P02679; -; . DNASU 2266; -; . Ensembl ENST00000336098; ENSP00000336829; ENSG00000171557. [P02679-1]; . Ensembl ENST00000404648; ENSP00000384860; ENSG00000171557. [P02679-2]; . GeneID 2266; -; . KEGG hsa:2266; -; . UCSC uc003iog.4; human. [P02679-1]; . CTD 2266; -; . DisGeNET 2266; -; . GeneCards FGG; -; . HGNC HGNC:3694; FGG; . HPA CAB033120; -; . HPA HPA027529; -; . MalaCards FGG; -; . MIM 134850; gene; . MIM 202400; phenotype; . MIM 616004; phenotype; . neXtProt NX_P02679; -; . OpenTargets ENSG00000171557; -; . Orphanet 98880; Familial afibrinogenemia; . Orphanet 98881; Familial dysfibrinogenemia; . Orphanet 248408; Familial hypodysfibrinogenemia; . Orphanet 101041; Familial hypofibrinogenemia; . PharmGKB PA430; -; . eggNOG KOG2579; Eukaryota; . eggNOG ENOG410ZYS4; LUCA; . GeneTree ENSGT00760000118809; -; . HOVERGEN HBG099783; -; . InParanoid P02679; -; . KO K03905; -; . PhylomeDB P02679; -; . TreeFam TF336658; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-140875; Common Pathway of Fibrin Clot Formation; . Reactome R-HSA-216083; Integrin cell surface interactions; . Reactome R-HSA-354192; Integrin alphaIIb beta3 signaling; . Reactome R-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; . Reactome R-HSA-372708; p130Cas linkage to MAPK signaling for integrins; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-5686938; Regulation of TLR by endogenous ligand; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . ChiTaRS FGG; human; . EvolutionaryTrace P02679; -; . GeneWiki FGG; -; . GenomeRNAi 2266; -; . PMAP-CutDB P02679; -; . PRO PR:P02679; -; . Proteomes UP000005640; Chromosome 4; . Bgee ENSG00000171557; -; . CleanEx HS_FGG; -; . ExpressionAtlas P02679; baseline and differential; . Genevisible P02679; HS; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0005938; C:cell cortex; IEA:Ensembl; . GO GO:0009986; C:cell surface; IDA:BHF-UCL; . GO GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005577; C:fibrinogen complex; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0031091; C:platelet alpha granule; IDA:BHF-UCL; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0050839; F:cell adhesion molecule binding; IPI:BHF-UCL; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0005102; F:receptor binding; IPI:BHF-UCL; . GO GO:0005198; F:structural molecule activity; IDA:BHF-UCL; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0072378; P:blood coagulation; fibrin clot formation; IDA:UniProtKB GO GO:0007160; P:cell-matrix adhesion; IDA:BHF-UCL; . GO GO:0043623; P:cellular protein complex assembly; IDA:BHF-UCL; . GO GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl; . GO GO:0071354; P:cellular response to interleukin-6; IEA:Ensembl; . GO GO:0030198; P:extracellular matrix organization; TAS:Reactome; . GO GO:0042730; P:fibrinolysis; IDA:UniProtKB; . GO GO:2000352; P:negative regulation of endothelial cell apoptotic process; IDA:BHF-UCL; . GO GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL; . GO GO:0090331; P:negative regulation of platelet aggregation; IEA:Ensembl; . GO GO:0031639; P:plasminogen activation; IDA:UniProtKB; . GO GO:0070527; P:platelet aggregation; IDA:BHF-UCL; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0036345; P:platelet maturation; IEA:Ensembl; . GO GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL; . GO GO:0045921; P:positive regulation of exocytosis; IDA:BHF-UCL; . GO GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IDA:BHF-UCL; . GO GO:0090277; P:positive regulation of peptide hormone secretion; IDA:BHF-UCL; . GO GO:0050714; P:positive regulation of protein secretion; IDA:BHF-UCL; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; NAS:BHF-UCL; . GO GO:0045907; P:positive regulation of vasoconstriction; IDA:BHF-UCL; . GO GO:0051258; P:protein polymerization; IMP:BHF-UCL; . GO GO:0009306; P:protein secretion; IMP:UniProtKB; . GO GO:0051592; P:response to calcium ion; IDA:BHF-UCL; . GO GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome; . CDD cd00087; FReD; 1; . Gene3D 3.90.215.10; -; 1; . Gene3D 4.10.530.10; -; 1; . InterPro IPR014716; Fibrinogen_a/b/g_C_1; . InterPro IPR014715; Fibrinogen_a/b/g_C_2; . InterPro IPR002181; Fibrinogen_a/b/g_C_dom; . InterPro IPR012290; Fibrinogen_a/b/g_coil_dom; . InterPro IPR020837; Fibrinogen_CS; . Pfam PF08702; Fib_alpha; 1; . Pfam PF00147; Fibrinogen_C; 1; . SMART SM00186; FBG; 1; . SMART SM01212; Fib_alpha; 1; . SUPFAM SSF56496; SSF56496; 1; . PROSITE PS00514; FIBRINOGEN_C_1; 1; . PROSITE PS51406; FIBRINOGEN_C_2; 1; .

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